Evaluation Of Lrrk2 I1371v Mutation On Cellular Pathogenesis Of Parkinson Disease Using Patient-Spec
33/4/2019-TF/Rare/BMS
ICMR
Feb. 3, 2020
Feb. 2, 2023
Three Year
Parkinson Disease
In vitro study
Quantitative data
To evaluate LRRK2-I1371V mutation found in Indian-ethnicity on cellular pathogenesis in dopaminergic neurons with respect to ontogeny, function, and α-synuclein phosphorylation-machinery
Induced pluripotent stem cells, parkinson's disease LRRK2 I1371, mutation, Indian ethnicity PD patie
The study showed the phenotype of PD pathology mimicking in petri-dish for the LRRK2 I1371V variant in turn confirming the pathogenicity of this variant. Also, the patient-iPSCs derived cell-type can serve as a suitable cellular platform for evaluating ontology and cellular properties and events
42,99,272/-
Dr. Indrani Datta/None/National Institute of Mental Health and Neuro Sciences