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Process Development of Risdiplam, Cladribine and Palovarotene: Drugs for Rare/Orphan Diseases
Temp 5

DST
May 12, 2023

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Rare disorder
Invitro assay

Quantitative data
• To develop a cost-effective process for the synthesis of Cladribine, used for the treatment of adult patients with highly active forms of relapsing-remitting multiple sclerosis (MS) and for treating Langerhans cell histiocytosis (LCH). • To develop a process for the synthesis of palovarotene used for the treatment of heterotopic ossification (HO) and fibrodysplasiaossificance progressive (FOP).

Risdiplam, Cladribine, Palvoarotone, Rare disorders, Orphan drugs, Relaing-Remitting multiple sclerosis, Langerhans cell histiocytosis, Heterotopic ossification, Fibrodysplasia ossificane progressive
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Dr. Raju Adepu/None/CSIR-IICT, Hyderabad