Understanding The Mechanism Of Action Of A Novel Chemical Cross-Linker Designed To Treat Keratoconus
33/25/2019-TF/Rare/BMS
ICMR
May 4, 2020
May 3, 2023
Three Year
Keratoconus
In vitro study
Quantitative data
To find the mechanism of action of the novel chemical cross-linker in inducing the stiffening of the cornea
Novel chemical cross-linker; Mechanisms; keratoconus; signalling molecules; collagen matrix; eye-dro
The novel chemical crosslinker seems to be associated with the inhibition of signalling pathways involving MMP-2 and MMP-9 and other proteases leading to corneal stiffening and preventing the degradation of collagen matrix, thereby halting the progression of keratoconus disease
51,64,148/-
Dr. Ramprasad Riridhara Gopalan Obula/None/Deptt. of Proteomics , Aravind Medical Research Foundation Madurai