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Title Evaluation Of Read Through Compounds For Nonsense Suppression Of Atm Mutations In Indian Patients

File number 33/24/2019-TF/Rare/BMS

Funding agency ICMR

Start date Dec. 1, 2020

End Date Nov. 30, 2023

Duration Three Year

Disease category Nonsense Suppression

Type of study None

Type of data None

Aims of objective To characterise the read through activity of SMRT compounds RTC13, RTC14, and their analogues , To assess the efficacy of nonsense suppression of SMRT compounds RTC13, RTC14, GJ071 GJ072 and PTC124 on

Keyword Ataxia telangiectasia, ATM, premature truncating mutation, small molecular read through (SMRT) compo

Description None

Total Sanctioned budget 39,72,355/-

Principle Investigator Dr. Rashmi Shukla/None/Genetics Division, Department of pediatrics, AIIMS

CoPrincipal Investigator Madhulika Kabra/None/Genetics, AIIMS