Mechnaisms Of Retinal Degneration In Retinitis Pigmentosa Type 12: Role Of The Crumbs-Homology Prote
33/23/2019-TF/Rare/BMS
ICMR
July 7, 2020
July 6, 2023
Three Year
Retinitis Pigmentosa Type 12
In vitro study
Quantitative data
To determine components of CRB-1/-2 interactome & identify genes that are differentially regulated in CRB-1/-2 constructs. To understand role of CRB-1/-2 depletion on the phagocytosis function of RPE.
Retinitis pigmentosa 12, Crumbs-1, Crumbs-2, tight junctions, adherens junctions.
Cell culture based models of RP12 are being developed to serve as viable alternatives to animal models in order to better understand the patho-physiology of RP12. This work will help in devising strategies to inhibit the degradation of the RPE in retinitis pigmentosa type 12 and prevent loss of vision
34,25,532/-
Dr. Saima Aijaz/None/Special Centre for Molecular Medicine , JNU , Delhi