Exploring the molecular mechanisms underpinning arterial calcifications in ADCC/CALJA (a rare diseas
33/8/2019-TF/Rare/BMS
ICMR
Aug. 14, 2020
Aug. 13, 2023
Three Year
ADCC/CALJA
None
None
Initial aim is to engineer ACDC prevalent NT5E mutations in human vascular smooth muscle- and aortic endothelial cells by CRISPR-CAS9 gene editing and elucidate early plasticity changes such as EndMT
Vascular calcifications, genome editing, ACDC, ossification, Endothelial to Mesenchymal transition
None
71,20,354/-
Dr. Jyothi Prasanna/None/Manipal Institute of Regenerative Medicine